Quinapril is the drug, in the series of angiotensin converting enzyme (ACE) inhibitors used in cardiac ailments. Since\r\nquinapril has a short half-life, consecutive doses have to be administered. Formulating quinapril as a controlled release dosage\r\nform can minimize this disadvantage. In the present study a total of 14 formulations were studied and characterized on basis of\r\nbuoyancy and lag time. Among all the formulations F14 showed lag time of 0 minutes and remained floating for >24 hrs. Thus\r\nthe formulation F14 was further investigated for formulation of quinapril floating tablets using suitable design. The effect of\r\nindependent variables on quality determinant parameters in a formulation was studied using 22 factorial design. The drug: total\r\npolymer ratio was considered as factor A and carbopol: ethyl cellulose ratio was considered as factor B. Diffusion coefficient and\r\ntime required for 50% of drug release was considered as the response variable. The regression statistics and ANOVA for\r\nresponse variable diffusion coefficient were calculated. From the ANOVA it is observed that the ââ?¬Ë?Fââ?¬â?¢ value is greater than\r\nââ?¬Ë?significance Fââ?¬â?¢ value indicating the model significantly predicts the effect of considered factors. From the regression statistics\r\npolynomial equation was derived. By utilizing the polynomial equations obtained the optimized formulation and their\r\ndesirability were calculated. The formulation with maximum desirability was chosen as the optimized formula.
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